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Negative feedback couples Hippo pathway activation with Kibra degradation independent of Yorkie-mediated transcription
Abstract The Hippo pathway regulates tissue growth in many animals. Multiple upstream components promote Hippo…
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TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation
Abstract Protein interaction is critical molecular regulatory activity underlining cellular functions and prec…
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Celsr1 adhesive interactions mediate the asymmetric organization of planar polarity complexes
Planar cell polarity protein Celsr1 clusters into punctate assemblies through lateral cis-interactions to func…
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A small-molecule ICMT inhibitor delays senescence of Hutchinson-Gilford progeria syndrome cells
Knockout of the methyltransferase ICMT prevents progerin methylation and improves survival in mice with Hutchi…
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Non-genetic inheritance restraint of cell-to-cell variation
Abstract Heterogeneity in physical and functional characteristics of cells (e.g. size, cycle time, growth rate…
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Pre-existing bilayer stresses modulate triglyceride accumulation in the ER versus lipid droplets
Abstract Cells store energy in the form of neutral lipids packaged into micrometer-sized organelles named lipi…
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Robustness of the microtubule network self-organization in epithelia
Abstract Robustness of biological systems is crucial for their survival, however, for many systems its origin …
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NAD+ enhances ribitol and ribose rescue of α-dystroglycan functional glycosylation in human FKRP-mutant myotubes
Abstract Mutations in the fukutin-related protein (FKRP) cause Walker-Warburg Syndrome (WWS), a severe form of…
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Cytoplasmic chromatin fragments—from mechanisms to therapeutic potential
Cytoplasmic chromatin fragment formation pathways in senescent cells are a potential therapeutic target for mo…
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Aging, Geroscience and Longevity: A Special Issue
eLife is pleased to present a Special Issue to highlight recent advances in the mechanistic understanding of a…
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Research: A new era for research into aging
eLife is publishing a special issue on aging, geroscience and longevity to mark the rapid progress made in thi…
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Generation of stress fibers through myosin-driven re-organization of the actin cortex
Abstract Contractile actomyosin bundles, stress fibers, govern key cellular processes including migration, adh…
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SUMO is a pervasive regulator of meiosis
Abstract Protein modification by SUMO helps orchestrate the elaborate events of meiosis to faithfully produce …
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ATP activation of peritubular cells drives testicular sperm transport
Purinergic signaling controls mammalian sperm transport. Abstract Spermatogenesis, the complex process of male…
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A flagellate-to-amoeboid switch in the closest living relatives of animals
Abstract Amoeboid cells are fundamental to animal biology and broadly distributed across animal diversity, but…
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Ca2+ signaling driving pacemaker activity in submucosal interstitial cells of Cajal in the murine colon
An optogenetic dual-color Ca2+-imaging approach shows how submucosal pacemaker-cells, interstitial cells of Ca…
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Stable transplantation of human mitochondrial DNA by high-throughput, pressurized isolated mitochondrial delivery
Abstract Generating mammalian cells with specific mtDNA-nDNA combinations is desirable but difficult to achiev…
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ARL3 activation requires the co-GEF BART and effector-mediated turnover
Abstract The ADP-ribosylation factor-like 3 (ARL3) is a ciliopathy G-protein which regulates the ciliary traff…
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Epigenetic regulation of Wnt7b expression by the cis-acting long noncoding RNA Lnc-Rewind in muscle stem cells
Abstract Skeletal muscle possesses an outstanding capacity to regenerate upon injury due to the adult muscle s…
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BUB-1 targets PP2A:B56 to regulate chromosome congression during meiosis I in C. elegans oocytes
BUB-1 recruits PP2A/B56 to regulate chromosome congression in meiosis I. Abstract Protein Phosphatase 2A (PP2A…