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Membrane binding controls ordered self-assembly of animal septins
Nanoscaleimaging reveals that animal septins form dense filamentous networks on biomimeticlipid membranes, exp…
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Adiponectin preserves metabolic fitness during aging
Adiponectin is an essential regulator for healthspan and is indispensable for sustaining a normal lifespan. Ab…
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CM1-driven assembly and activation of yeast γ-tubulin small complex underlies microtubule nucleation
Cryo-EM structures reveal that the conserved CM1 motif drives γTuRC assembly by bridging adjacent γTuSC. Abstr…
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Combinatorial deployment of F-actin regulators to build complex 3D actin structures in vivo
Abstract Despite extensive studies on the actin regulators that direct microfilament dynamics, how these regul…
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Receptor-mediated mitophagy regulates EPO production and protects against renal anemia
Abstract Erythropoietin (EPO) drives erythropoiesis and is secreted mainly by the kidney upon hypoxic or anemi…
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Defective apoptotic cell contractility provokes sterile inflammation, leading to liver damage and tumour suppression
In the absence of ROCK1 activation by caspases, apoptotic cells don’t undergo typical morphological changes, l…
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eNOS-induced vascular barrier disruption in retinopathy by c-Src activation and tyrosine phosphorylation of VE-cadherin
Vascular leakage from pathological vessels in retinopathy aggravates the disease, but endothelial junction sta…
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The transcription factor Rreb1 regulates epithelial architecture, invasiveness and vasculogenesis in early mouse embryos
Abstract Ras-responsive element-binding protein 1 (Rreb1) is a zinc-finger transcription factor acting downstr…
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Flagellar energetics from high-resolution imaging of beating patterns in tethered mouse sperm
Abstract We demonstrate a technique for investigating the energetics of flagella or cilia. We record the plana…
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Compartment-specific opioid receptor signaling is selectively modulated by different Dynorphin peptides
Abstract Many signal transduction systems have an apparent redundancy built into them, where multiple physiolo…
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Integration of locomotion and auditory signals in the mouse inferior colliculus
Robust and wide-spread locomotion-related neural signals, revealed in the mouse auditory midbrain, suggest tha…
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Clusters of cooperative ion channels enable a membrane-potential-based mechanism for short-term memo…
Independently gating ion channels typically act fast within milliseconds, but cooperative interactions within …
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β11-12 linker isomerization governs Acid-sensing ion channel desensitization and recovery
Abstract Acid-sensing ion channels (ASICs) are neuronal sodium-selective channels activated by reductions in e…
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The contribution of temporal coding to odor coding and odor perception in humans
Human participants fail to discriminate between odor sequences that activate the same neurons at different ord…
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Analysis of zebrafish periderm enhancers facilitates identification of a regulatory variant near hum…
Abstract Genome wide association studies for non-syndromic orofacial cleft (OFC) have identified single nucleo…
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Invariant representations of mass in the human brain
A network of brain regions implicated in physical inference represents abstract, generalizable variables used …
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CXCL12-induced rescue of cortical dendritic spines and cognitive flexibility
Unveiling a novel role of the chemokine CXCL12 in the mature brain that opens up new lines of investigation fo…
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Phrenic-specific transcriptional programs shape respiratory motor output
Molecular programs regulated by Hox5 transcription factors establish a set of inhibitory inputs onto phrenic m…
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Deep learning models predict regulatory variants in pancreatic islets and refine type 2 diabetes ass…
Combination of deep learning models trained on tissue-specific genomic data and fine-mapping approaches suppor…
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Recruitment of mRNAs to P granules by condensation with intrinsically-disordered proteins
The intrinsically-disordered protein MEG-3 recruits mRNAs to P granules by forming gel-like condensates with r…