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Glycolytic preconditioning in astrocytes mitigates trauma-induced neurodegeneration
Promoting a Warburg-like shift in astrocytic metabolism through reduced mitochondrial electron transport accom…
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Filopodia powered by class X myosin promote fusion of mammalian myoblasts
Abstract Skeletal muscle fibers are multinucleated cellular giants formed by the fusion of mononuclear myoblas…
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Structural basis for membrane recruitment of ATG16L1 by WIPI2 in Autophagy
Abstract Autophagy is a cellular process that degrades cytoplasmic cargo by engulfing it in a double membrane …
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Edge-strand of BepA interacts with immature LptD on the β-barrel assembly machine to direct it to on- and off-pathways
In vivo crosslinking approaches revealed that the edge-strand of Escherichia coli metallopeptidase BepA intera…
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An engineered transcriptional reporter of protein localization identifies regulators of mitochondrial and ER membrane protein trafficking in high-thro…
HiLITR is a molecular reporter of protein localization that enables straightforward, large-scale, fluorescence…
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Endothelial Pannexin 1-TRPV4 channel signaling lowers pulmonary arterial pressure in mice
Abstract Pannexin 1 (Panx1), an ATP-efflux pathway, has been linked with inflammation in pulmonary capillaries…
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β-hydroxybutyrate accumulates in the rat heart during low-flow ischaemia with implications for functional recovery
β-Hydroxybutyrate accumulates in the perfused rat heart during ischaemia, driven by flux through both HMGCS an…
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Science Forum: Vision, challenges and opportunities for a Plant Cell Atlas
A Plant Cell Atlas that shows the location and organization of molecules at cellular and tissue levels could h…
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Imaging cytoplasmic lipid droplets in vivo with fluorescent perilipin 2 and perilipin 3 knock-in zebrafish
Fluorescent perilipin zebrafish lines are powerful new tools for studying lipid droplet dynamics in health and…
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A bone-specific adipogenesis pathway in fat-free mice defines key origins and adaptations of bone marrow adipocytes with age and disease
A novel secondary adipogenesis pathway is defined that is unique to the bone marrow and is activated with age …
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TRPC3 and NALCN channels drive pacemaking in substantia nigra dopaminergic neurons
The non-selective Na+ leak channel (NALCN) and the transient receptor potential 3 channel (TRPC3) cooperate in…
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Intracellular functions and motile properties of bi-directional kinesin-5 Cin8 are regulated by neck linker docking
Precise hydrogen-bond stabilization of the neck linker docking onto the catalytic motor domain, is crucial for…
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PRMT5>regulates ovarian follicle development by facilitating Wt1 translation
Abstract Protein arginine methyltransferase 5 (Prmt5) is the major type II enzyme responsible for symmetric di…
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MACF1 controls skeletal muscle function through the microtubule-dependent localization of extra-synaptic myonuclei and mitochondria biogenesis
Abstract Skeletal muscles are composed of hundreds of multinucleated muscle fibers (myofibers) whose myonuclei…
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Distinct roles of nonmuscle myosin II isoforms for establishing tension and elasticity during cell morphodynamics
The mechanical response of adherent cells in structured environments is shown to be shaped by the intricate in…
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The cAMP effector PKA mediates Moody GPCR signaling in Drosophila blood–brain barrier formation and maturation
A polarized Moody/protein kinase A pathway plays an unrecognized central role in controlling the enormous cell…
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The pro-regenerative effects of HyperIL6 in drug induced liver injury are unexpectedly due to competitive inhibition of IL11 signaling
Abstract It is generally accepted that IL6-mediated STAT3 signaling in hepatocytes, mediated via glycoprotein …
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Augmin deficiency in neural stem cells causes p53-dependent apoptosis and aborts brain development
Abstract Microtubules that assemble the mitotic spindle are generated by centrosomal nucleation, chromatin-med…
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Analysis of meiosis in Pristionchus pacificus reveals plasticity in homolog pairing and synapsis in the nematode lineage
Abstract Meiosis is conserved across eukaryotes yet varies in the details of its execution. Here we describe a…
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Emergence of a smooth interface from growth of a dendritic network against a mechanosensitive contractile material
Abstract Structures and machines require smoothening of raw materials. Self-organized smoothening guides cell …